Currently we have 4 major FDA approved hyaluronic acid fillers on the market:
Restylane
Perlane
Juvederm Ultra
Juvederm Ultra Plus
Restylane and Perlane are produced by Medicis. They are similar products, but Perlane has bigger size particles, and is better for correction of deeper, larger troughs, for example deep, wide nasolabial folds.
Juvederm Ultra and Ultra Plus come from Allergan. Juvederm Ultra is similar to Restylane, and Juvederm Ultra Plus is similar to Perlane, with larger size particle, need for deeper injection, and suitability for larger size defect correction.
As far as the difference between Restylane and Juvederm is concerned, I tell my patients that it is similar to the one between Coke and Pepsi - mostly depends on the personal preference. There is slightly more of a spread effect from Juvederm, and slightly more localized volume correction from Restylane, but the difference most of the time is minimal. They last about the same, and the cost in our clinic is the same.
While it is common to hear that Restylane causes more lumps, I believe it is more dependent upon the injector. If you have a good, experienced injector, you will do great with Restylane in the lips. We have been doing it for years.
